It's hard to say that ankle-carry is more comfortable, for numerous reasons. First off, due to the constant motion, you really need to have the weapon strapped on fairly tight. Second, the added weight on one side can be a little difficult for some to get accustomed to. Third, you have another obstruction to catch on things, including your other ankle (if worn on the inside). And lastly, it can ride a little funny, and cause a bulge down around the ankle,
That's not to say that it can't work, as I do have a couple of holsters for things like J-frames and baby Glocks -- but I tend to find reasons NOT to wear them.
Normally, if ankle-carry serves a purpose, it tends to be from the UDC perspective -- as access to the ankle area is somewhat difficult, and immobilizes you while you are retrieving the weapon. In other words, you can back up, walk, run, or otherwise engage/defend while accessing from a belt-carry position (some of those could be limited if that method is cross-draw, though).
Just my thoughts, and happy holidays.